Oral Squamous Cell Carcinoma could be related to coca chewers in Northern Argentina

Oral Squamous Cell Carcinoma (OSCC) was previously described as the five “S” disease regarding smoking, spirits, syphilis, spices, and sharp/ septic teeth. Chewing of plant-derived compounds such as betel and areca nut is a well-known habit associated with oral potentially malignant disorders (OPMD) such as submucosal oral fibrosis and OSCC. Both of these conditions are frequent in Southeast Asia.